Research conducted in various settings suggests that preparation and support for online instructors should be considered separately from comparable efforts for instructors in face-to-face environments. However, few studies provide empirical data that outline the ways in which preparation to teach online should differ, and only a handful link these practices to measurable outcomes that help define what is meant by effective. PBS TeacherLine’s model presents an opportunity to examine a comprehensive, well-established effort to prepare and support instructors of exclusively online courses. Results from a yearlong study illustrate PBS TeacherLine’s successes and explores their relationship with outcomes such as instructor retention, quality of online instruction, satisfaction with support received, and favorable learner course grades and re-enrollment rates. Findings reveal promising practices for preparing and supporting any online faculty, whether in k-12 or higher education, and suggest outcomes that may be appropriate for characterizing the effectiveness of these efforts.